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2-MDP - 版本历史
2026-07-11T18:32:51Z
在这个wiki上该页的修订历史
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2026-05-28T01:33:46Z
<p>使用<a href="/index.php?title=WP:HOTCAT&action=edit&redlink=1" class="new" title="WP:HOTCAT（页面不存在）">HotCat</a>已添加<a href="/wiki/Category:%E4%BC%AF%E8%83%BA" title="Category:伯胺">Category:伯胺</a></p>
<p><b>新页面</b></p><div>{{Drugbox<br />
| Verifiedfields = changed<br />
| Watchedfields = changed<br />
| verifiedrevid = 477213709<br />
| IUPAC_name = 3-amino-2-methyl-1,1-di(phenyl)propan-1-ol<br />
| image = 2-MDP.svg<br />
| image_class = skin-invert-image<br />
| width = 150<br />
<br />
<!--Clinical data--><br />
| tradename = <br />
| legal_status = <br />
| routes_of_administration =<br />
<br />
<!--Pharmacokinetic data--><br />
| metabolism = <br />
| elimination_half-life = <br />
| excretion =<br />
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<!--Identifiers--><br />
| index2_label = HCl<br />
<!-- | index3_label = levo --><br />
| CAS_number_Ref = {{cascite|correct|CAS}}<br />
| CAS_number = 14326-31-9<br />
| CAS_number2_Ref = {{cascite|correct|CAS}}<br />
| CAS_number2 = 14185-05-8<br />
| UNII_Ref = {{fdacite|correct|FDA}}<br />
| UNII = B6FTK35FGC<br />
| UNII2_Ref = {{fdacite|correct|FDA}}<br />
| UNII2 = TJH732RKT9<br />
| PubChem = 26538<br />
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}<br />
| ChemSpiderID = 24719<br />
<br />
<!--Chemical data--><br />
| C=16 | H=19 | N=1 | O=1 <br />
| smiles = OC(c1ccccc1)(c2ccccc2)C(C)CN<br />
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}<br />
| StdInChI = 1S/C16H19NO/c1-13(12-17)16(18,14-8-4-2-5-9-14)15-10-6-3-7-11-15/h2-11,13,18H,12,17H2,1H3<br />
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}<br />
| StdInChIKey = XGYCHIPEPHYUIH-UHFFFAOYSA-N<br />
}}<br />
'''2-MDP'''也称为'''U-23807A'''是一种[[氮化合物|含氮]][[有机化合物]]，分子式[[C16H19NO|{{chem2<br />
|C16H19NO}}]]，为[[Upjohn]]研发的[[NMDA受体拮抗剂]]，在动物体内有[[苯环己哌啶]]（PCP）类似的功效，可作为[[解离剂]]和[[麻醉藥|麻醉剂]]<ref name="pmid6718449">{{cite journal | vauthors = Tang AH, Cangelosi AA, Code RA, Franklin SR | title = Phencyclidine-like behavioral effects of 2-methyl-3,3-diphenyl-3-propanolamine (2-MDP) | journal = Pharmacology, Biochemistry, and Behavior | volume = 20 | issue = 2 | pages = 209–213 | date = February 1984 | pmid = 6718449 | doi = 10.1016/0091-3057(84)90244-2 | s2cid = 38908019 }}</ref><ref name="pmid3511477">{{cite journal | vauthors = Blake JC, Davies SN, Church J, Martin D, Lodge D | title = 2-Methyl-3,3-diphenyl-3-propanolamine (2-MDP) selectively antagonises N-methyl-aspartate (NMA) | journal = Pharmacology, Biochemistry, and Behavior | volume = 24 | issue = 1 | pages = 23–25 | date = January 1986 | pmid = 3511477 | doi = 10.1016/0091-3057(86)90038-9 | s2cid = 29762524 }}</ref>。<br />
<br />
[[File:U-23,807A synthesis.svg|thumb|center|500px|class=skin-invert-image|2-MDP可由[[二苯基甲酮]]为原料合成<ref>{{cite journal | vauthors = Moffett RB, Pickering TL | title = Central nervous system agents. 2. Synthesis of diphenyl primary and secondary aminopropanols | journal = Journal of Medicinal Chemistry | volume = 14 | issue = 11 | pages = 1100–1106 | date = November 1971 | pmid = 5115211 | doi = 10.1021/jm00293a019 }}</ref>]]<br />
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==参考文献==<br />
{{Reflist}}<br />
<br />
[[Category:解离性药物]]<br />
[[Category:叔醇]]<br />
[[Category:伯胺]]</div>
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