编辑“︁UBTF”︁

{{PBB|geneid=7343}}
'''核仁转录因子1'''（Nucleolar transcription factor 1）又叫'''上游结合转录因子'''（Upstream binding transcription factor，缩写'''UBTF'''）或'''上游结合因子1'''（Upstream binding factor 1，缩写'''UBF1'''）是一种由人类[[基因]]''UBTF'' 所编码的[[蛋白质]]<ref name="pmid9126496">{{cite journal | author = Matera AG, Wu W, Imai H, O'Keefe CL, Chan EK | title = Molecular cloning of the RNA polymerase I transcription factor hUBF/NOR-90 (UBTF) gene and localization to 17q21.3 by fluorescence in situ hybridization and radiation hybrid mapping | journal = Genomics | volume = 41 | issue = 1 | pages = 135–8 |date=May 1997 | pmid = 9126496 | pmc =  | doi = 10.1006/geno.1997.4647 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: UBTF upstream binding transcription factor, RNA polymerase I| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7343| accessdate = }}</ref>。
==功能==
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UBTF是[[18s rRNA|18S]]、[[5.8S rRNA|5.8S]]和[[28S rRNA|28S的核糖体RNA]]的转录所必须的转录因子，和SL1因子（一个四聚体，包括一个[[TATA结合蛋白]]和3个转录辅助因子{{le|TAF1|TAF1}}）共同起作用。在人体中存在94和97kD的两种UBF多肽链。UBF是一种核仁磷酸化蛋白（nucleolar phosphoprotein），同时具有DNA结合结构域和反式激活结构域，通过[[HMG盒]]结合到人rRNA[[启动子]]的核心与上游部位。<ref name="entrez" />

==相互作用==
UBTF已知能与{{le|酪蛋白激酶2α亚基|Casein kinase 2, alpha 1}}<ref name=pmid7651819>{{cite journal |last=Voit |first=R |authorlink= |coauthors=Kuhn A, Sander E E, Grummt I |date=July 1995 |title=Activation of mammalian ribosomal gene transcription requires phosphorylation of the nucleolar transcription factor UBF |journal=Nucleic Acids Res. |volume=23 |issue=14 |pages=2593–9 |publisher= |location = ENGLAND| issn = 0305-1048| pmid = 7651819 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1093/nar/23.14.2593 |pmc=307079 }}</ref>、[[TAF1C]]<ref name=pmid11698641>{{cite journal |last=Voit |first=R |authorlink= |coauthors=Grummt I |date=November 2001 |title=Phosphorylation of UBF at serine 388 is required for interaction with RNA polymerase I and activation of rDNA transcription |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=98 |issue=24 |pages=13631–6 |publisher= |location = United States| issn = 0027-8424| pmid = 11698641 |doi = 10.1073/pnas.231071698 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=61092 }}</ref><ref name=pmid10913176>{{cite journal |last=Zhai |first=W |authorlink= |coauthors=Comai L |date=August 2000 |title=Repression of RNA Polymerase I Transcription by the Tumor Suppressor p53 |journal=Mol. Cell. Biol. |volume=20 |issue=16 |pages=5930–8 |publisher= |location = UNITED STATES| issn = 0270-7306| pmid = 10913176 | bibcode = | oclc =| id = | url =https://archive.org/details/sim_molecular-and-cellular-biology_2000-08_20_16/page/5930| language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1128/MCB.20.16.5930-5938.2000 |pmc=86070 }}</ref>、[[视网膜母细胞瘤蛋白]]<ref name=pmid11042686>{{cite journal |last=Hannan |first=K M |authorlink= |coauthors=Hannan R D, Smith S D, Jefferson L S, Lun M, Rothblum L I |date=October 2000 |title=Rb and p130 regulate RNA polymerase I transcription: Rb disrupts the interaction between UBF and SL-1 |journal=Oncogene |volume=19 |issue=43 |pages=4988–99 |publisher= |location = ENGLAND| issn = 0950-9232| pmid = 11042686 |doi = 10.1038/sj.onc.1203875 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>和[[TAF1]]<ref name=pmid12498690>{{cite journal |last=Lin |first=Chih-Yin |authorlink= |coauthors=Tuan JoAnn, Scalia Pierluigi, Bui Tiffany, Comai Lucio |date=Dec 2002 |title=The cell cycle regulatory factor TAF1 stimulates ribosomal DNA transcription by binding to the activator UBF |journal=Curr. Biol. |volume=12 |issue=24 |pages=2142–6 |publisher= |location = England| issn = 0960-9822| pmid = 12498690 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1016/S0960-9822(02)01389-1 }}</ref>进行[[蛋白質交互作用|交互作用]]。

==参考文献==
{{Reflist}}

==延伸阅读==
{{Refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Chan EK, Imai H, Hamel JC, Tan EM |title=Human autoantibody to RNA polymerase I transcription factor hUBF. Molecular identity of nucleolus organizer region autoantigen NOR-90 and ribosomal RNA transcription upstream binding factor | url=https://archive.org/details/sim_journal-of-experimental-medicine_1991-11-01_174_5/page/1238 |journal=J. Exp. Med. |volume=174 |issue= 5 |pages= 1239–44 |year= 1991 |pmid= 1940801 |doi=10.1084/jem.174.5.1239  | pmc=2119007  }}
*{{cite journal  | author=Jantzen HM, Admon A, Bell SP, Tjian R |title=Nucleolar transcription factor hUBF contains a DNA-binding motif with homology to HMG proteins | url=https://archive.org/details/sim_nature-uk_1990-04-26_344_6269/page/830 |journal=Nature |volume=344 |issue= 6269 |pages= 830–6 |year= 1990 |pmid= 2330041 |doi= 10.1038/344830a0 }}
*{{cite journal  | author=Bell SP, Learned RM, Jantzen HM, Tjian R |title=Functional cooperativity between transcription factors UBF1 and SL1 mediates human ribosomal RNA synthesis | url=https://archive.org/details/sim_science_1988-09-02_241_4870/page/1192 |journal=Science |volume=241 |issue= 4870 |pages= 1192–7 |year= 1988 |pmid= 3413483 |doi=10.1126/science.3413483  }}
*{{cite journal  | author=Voit R, Kuhn A, Sander EE, Grummt I |title=Activation of mammalian ribosomal gene transcription requires phosphorylation of the nucleolar transcription factor UBF |journal=Nucleic Acids Res. |volume=23 |issue= 14 |pages= 2593–9 |year= 1995 |pmid= 7651819 |doi=10.1093/nar/23.14.2593  | pmc=307079  }}
*{{cite journal  | author=Hempel WM |title=The species-specific RNA polymerase I transcription factor SL-1 binds to upstream binding factor | url=https://archive.org/details/sim_molecular-and-cellular-biology_1996-02_16_2/page/557 |journal=Mol. Cell. Biol. |volume=16 |issue= 2 |pages= 557–63 |year= 1996 |pmid= 8552083 |doi=  | pmc=231034 | author2=Cavanaugh AH  | author3=Hannan RD  | display-authors=3  | last4=Taylor  | first4=L  | last5=Rothblum  | first5=LI  }}
*{{cite journal  | author=Hanada K |title=RNA polymerase I associated factor 53 binds to the nucleolar transcription factor UBF and functions in specific rDNA transcription | url=https://archive.org/details/sim_embo-journal_1996-05-01_15_9/page/2216 |journal=EMBO J. |volume=15 |issue= 9 |pages= 2217–26 |year= 1996 |pmid= 8641287 |doi=  | pmc=450146 | author2=Song CZ  | author3=Yamamoto K  | display-authors=3  | last4=Yano  | first4=K  | last5=Maeda  | first5=Y  | last6=Yamaguchi  | first6=K  | last7=Muramatsu  | first7=M  }}
*{{cite journal  | author=Pluta AF, Earnshaw WC |title=Specific interaction between human kinetochore protein CENP-C and a nucleolar transcriptional regulator | url=https://archive.org/details/sim_journal-of-biological-chemistry_1996-08-02_271_31/page/18766 |journal=J. Biol. Chem. |volume=271 |issue= 31 |pages= 18767–74 |year= 1996 |pmid= 8702533 |doi=10.1074/jbc.271.31.18767  }}
*{{cite journal  | author=Whitehead CM, Winkfein RJ, Fritzler MJ, Rattner JB |title=ASE-1: a novel protein of the fibrillar centres of the nucleolus and nucleolus organizer region of mitotic chromosomes |journal=Chromosoma |volume=106 |issue= 8 |pages= 493–502 |year= 1998 |pmid= 9426281 |doi=10.1007/s004120050271  }}
*{{cite journal  | author=Voit R, Hoffmann M, Grummt I |title=Phosphorylation by G1-specific cdk-cyclin complexes activates the nucleolar transcription factor UBF | url=https://archive.org/details/sim_embo-journal_1999-04-01_18_7/page/1890 |journal=EMBO J. |volume=18 |issue= 7 |pages= 1891–9 |year= 1999 |pmid= 10202152 |doi= 10.1093/emboj/18.7.1891  | pmc=1171274 }}
*{{cite journal  | author=Liu CJ, Wang H, Lengyel P |title=The interferon-inducible nucleolar p204 protein binds the ribosomal RNA-specific UBF1 transcription factor and inhibits ribosomal RNA transcription | url=https://archive.org/details/sim_embo-journal_1999-05-17_18_10/page/2844 |journal=EMBO J. |volume=18 |issue= 10 |pages= 2845–54 |year= 1999 |pmid= 10329630 |doi= 10.1093/emboj/18.10.2845  | pmc=1171365 }}
*{{cite journal  | author=Hannan KM |title=Rb and p130 regulate RNA polymerase I transcription: Rb disrupts the interaction between UBF and SL-1 |journal=Oncogene |volume=19 |issue= 43 |pages= 4988–99 |year= 2000 |pmid= 11042686 |doi= 10.1038/sj.onc.1203875 | author2=Hannan RD  | author3=Smith SD  | display-authors=3  | last4=Jefferson  | first4=L S  | last5=Lun  | first5=Mingyue  | last6=Rothblum  | first6=L I }}
*{{cite journal  | author=Kalousek I, Krízková P |title=Lymphocyte mitogenic transformation is accompanied by phosphorylation of the nucleolar transcription factor UBF |journal=Cell. Mol. Biol. (Noisy-le-grand) |volume=46 |issue= 7 |pages= 1163–71 |year= 2001 |pmid= 11075946 |doi=  }}
*{{cite journal  | author=Pelletier G |title=Competitive recruitment of CBP and Rb-HDAC regulates UBF acetylation and ribosomal transcription |journal=Mol. Cell |volume=6 |issue= 5 |pages= 1059–66 |year= 2002 |pmid= 11106745 |doi=10.1016/S1097-2765(00)00104-0 | author2=Stefanovsky VY  | author3=Faubladier M  | display-authors=3  | last4=Hirschler-Laszkiewicz  | first4=Iwona  | last5=Savard  | first5=Julie  | last6=Rothblum  | first6=Lawrence I.  | last7=Côté  | first7=Jacques  | last8=Moss  | first8=Tom  }}
*{{cite journal  | author=Miller G |title=hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters | url=https://archive.org/details/sim_embo-journal_2001-03-15_20_6/page/1372 |journal=EMBO J. |volume=20 |issue= 6 |pages= 1373–82 |year= 2001 |pmid= 11250903 |doi= 10.1093/emboj/20.6.1373  | pmc=145519 | author2=Panov KI  | author3=Friedrich JK  | display-authors=3  | last4=Trinkle-Mulcahy  | first4=Laura  | last5=Lamond  | first5=Angus I.  | last6=Zomerdijk  | first6=Joost C.B.M. }}
*{{cite journal  | author=Seither P, Iben S, Thiry M, Grummt I |title=PAF67, a novel protein that is associated with the initiation-competent form of RNA polymerase I |journal=Biol. Chem. |volume=382 |issue= 8 |pages= 1163–70 |year= 2002 |pmid= 11592397 |doi=10.1515/BC.2001.146  }}
*{{cite journal  | author=Voit R, Grummt I |title=Phosphorylation of UBF at serine 388 is required for interaction with RNA polymerase I and activation of rDNA transcription |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 24 |pages= 13631–6 |year= 2002 |pmid= 11698641 |doi= 10.1073/pnas.231071698  | pmc=61092 }}
*{{cite journal  | author=Stefanovsky VY |title=An immediate response of ribosomal transcription to growth factor stimulation in mammals is mediated by ERK phosphorylation of UBF |journal=Mol. Cell |volume=8 |issue= 5 |pages= 1063–73 |year= 2002 |pmid= 11741541 |doi=10.1016/S1097-2765(01)00384-7 | author2=Pelletier G  | author3=Hannan R  | display-authors=3  | last4=Gagnon-Kugler  | first4=Thérèse  | last5=Rothblum  | first5=Lawrence I  | last6=Moss  | first6=Tom  }}
*{{cite journal  | author=Andersen JS |title=Directed proteomic analysis of the human nucleolus |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1–11 |year= 2002 |pmid= 11790298 |doi=10.1016/S0960-9822(01)00650-9 | author2=Lyon CE  | author3=Fox AH  | display-authors=3  | last4=Leung  | first4=Anthony K.L.  | last5=Lam  | first5=Yun Wah  | last6=Steen  | first6=Hanno  | last7=Mann  | first7=Matthias  | last8=Lamond  | first8=Angus I.  }}
*{{cite journal  | author=Dühr S |title=Molecular analysis of the 5' region of human ribosomal transcription factor UBF |journal=DNA Seq. |volume=12 |issue= 4 |pages= 267–72 |year= 2002 |pmid= 11916260 |doi=10.3109/10425170109025001 | author2=Torres-Montaner A  | author3=Astola A  | display-authors=3  | last4=García-Cozar  | first4=F. J.  | last5=Pendón  | first5=C  | last6=Bolívar  | first6=J.  | last7=Valdivia  | first7=M. M.  }}
}}
{{Refend}}
{{PDB Gallery|geneid=7343}}

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