编辑“︁Template:PBB/6737”︁

{{GNF_Protein_box
 | Name = 三分模體包含蛋白質21（TRIM21）</br>Tripartite motif containing 21
 | image = Protein_TRIM21_PDB_2iwg.png
 | image_source = 兩分子TRIM21的[[晶體結構]]。其中，兩分子TRIM21[[C端]]的PRYSPRY[[結構域]]分別位於左上方和左下方。它們均與位於中央的IGHG1同質二聚體C區域結合。其中，多肽鏈的C端被渲染爲紅色，N端被渲染爲藍色<ref name="pmid17400754">{{PDB|2IWG}}; {{cite journal | author = James LC, Keeble AH, Khan Z, Rhodes DA, Trowsdale J | title = Structural basis for PRYSPRY-mediated tripartite motif (TRIM) protein function | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 104 | issue = 15 | pages = 6200–5 | date=April 2007 | pmid = 17400754 | pmc = 1851072 | doi = 10.1073/pnas.0609174104 | url = | issn = }}</ref>
 | PDB = {{PDB2|2IWG}}
 | HGNCid = 11312
 | MGIid = 106657
 | Symbol = TRIM21
 | AltSymbols =; RNF81; RO52; Ro/SSA; SSA; SSA1
 | IUPHAR = 
 | ChEMBL = 
 | OMIM = 109092
 | ECnumber = 6.3.2.-
 | Homologene = 2365
 | GeneAtlas_image1 = PBB_GE_TRIM21_204804_at_tn.png
 | GeneAtlas_image2 = 
 | GeneAtlas_image3 = 
 | Protein_domain_image = 
 | Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0004842 |text = ubiquitin-protein transferase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016874 |text = ligase activity}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}}
 | Component = {{GNF_GO|id=GO:0000932 |text = cytoplasmic mRNA processing body}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005654 |text = nucleoplasm}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0019005 |text = SCF ubiquitin ligase complex}} {{GNF_GO|id=GO:0030529 |text = ribonucleoprotein complex}}
 | Process = {{GNF_GO|id=GO:0000209 |text = protein polyubiquitination}} {{GNF_GO|id=GO:0006513 |text = protein monoubiquitination}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0016567 |text = protein ubiquitination}} {{GNF_GO|id=GO:0019221 |text = cytokine-mediated signaling pathway}} {{GNF_GO|id=GO:0031648 |text = protein destabilization}} {{GNF_GO|id=GO:0032088 |text = negative regulation of NF-kappaB transcription factor activity}} {{GNF_GO|id=GO:0032479 |text = regulation of type I interferon production}} {{GNF_GO|id=GO:0032481 |text = positive regulation of type I interferon production}} {{GNF_GO|id=GO:0032897 |text = negative regulation of viral transcription}} {{GNF_GO|id=GO:0045087 |text = innate immune response}} {{GNF_GO|id=GO:0045787 |text = positive regulation of cell cycle}} {{GNF_GO|id=GO:0046598 |text = positive regulation of viral entry into host cell}} {{GNF_GO|id=GO:0051091 |text = positive regulation of sequence-specific DNA binding transcription factor activity}} {{GNF_GO|id=GO:0051865 |text = protein autoubiquitination}} {{GNF_GO|id=GO:0060333 |text = interferon-gamma-mediated signaling pathway}} {{GNF_GO|id=GO:0070206 |text = protein trimerization}} {{GNF_GO|id=GO:0090086 |text = negative regulation of protein deubiquitination}} {{GNF_GO|id=GO:1902187 |text = negative regulation of viral release from host cell}}
 | Hs_EntrezGene = 6737
 | Hs_Ensembl = ENSG00000132109
 | Hs_RefseqmRNA = NM_003141
 | Hs_RefseqProtein = NP_003132
 | Hs_GenLoc_db = hg38
 | Hs_GenLoc_chr = 11
 | Hs_GenLoc_start = 4384897
 | Hs_GenLoc_end = 4393696
 | Hs_Uniprot = P19474
 | Mm_EntrezGene = 20821
 | Mm_Ensembl = ENSMUSG00000030966
 | Mm_RefseqmRNA = NM_001082552
 | Mm_RefseqProtein = NP_001076021
 | Mm_GenLoc_db = mm10
 | Mm_GenLoc_chr = 7
 | Mm_GenLoc_start = 102557922
 | Mm_GenLoc_end = 102565469
 | Mm_Uniprot = Q62191
 | path = PBB/6737
}}<noinclude>{{template reference list}}</noinclude>