编辑“︁Template:PBB/2068”︁

{{GNF_Protein_box
 | Name = Excision repair cross-complementing rodent repair deficiency, complementation group 2
 | image = 
 | image_source = 
 | PDB = 
 | HGNCid = 3434
 | MGIid = 95413
 | Symbol = ERCC2
 | AltSymbols =; COFS2; EM9; TTD; XPD
 | IUPHAR = 
 | ChEMBL = 
 | OMIM = 126340
 | ECnumber = 3.6.4.12
 | Homologene = 344
 | GeneAtlas_image1 = PBB_GE_ERCC2_213468_at_tn.png
 | GeneAtlas_image2 = 
 | GeneAtlas_image3 = 
 | Protein_domain_image = 
 | Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0004003 |text = ATP-dependent DNA helicase activity}} {{GNF_GO|id=GO:0004672 |text = protein kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008022 |text = protein C-terminus binding}} {{GNF_GO|id=GO:0008094 |text = DNA-dependent ATPase activity}} {{GNF_GO|id=GO:0008353 |text = RNA polymerase II carboxy-terminal domain kinase activity}} {{GNF_GO|id=GO:0043139 |text = 5'-3' DNA helicase activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} {{GNF_GO|id=GO:0047485 |text = protein N-terminus binding}} {{GNF_GO|id=GO:0051539 |text = 4 iron, 4 sulfur cluster binding}}
 | Component = {{GNF_GO|id=GO:0000441 |text = SSL2-core TFIIH complex}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005654 |text = nucleoplasm}} {{GNF_GO|id=GO:0005675 |text = holo TFIIH complex}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005819 |text = spindle}} {{GNF_GO|id=GO:0019907 |text = cyclin-dependent protein kinase activating kinase holoenzyme complex}} {{GNF_GO|id=GO:0071817 |text = MMXD complex}}
 | Process = {{GNF_GO|id=GO:0000075 |text = cell cycle checkpoint}} {{GNF_GO|id=GO:0000718 |text = nucleotide-excision repair, DNA damage removal}} {{GNF_GO|id=GO:0001666 |text = response to hypoxia}} {{GNF_GO|id=GO:0001701 |text = in utero embryonic development}} {{GNF_GO|id=GO:0006281 |text = DNA repair}} {{GNF_GO|id=GO:0006283 |text = transcription-coupled nucleotide-excision repair}} {{GNF_GO|id=GO:0006289 |text = nucleotide-excision repair}} {{GNF_GO|id=GO:0006360 |text = transcription from RNA polymerase I promoter}} {{GNF_GO|id=GO:0006361 |text = transcription initiation from RNA polymerase I promoter}} {{GNF_GO|id=GO:0006362 |text = transcription elongation from RNA polymerase I promoter}} {{GNF_GO|id=GO:0006363 |text = termination of RNA polymerase I transcription}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006367 |text = transcription initiation from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006368 |text = transcription elongation from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006370 |text = 7-methylguanosine mRNA capping}} {{GNF_GO|id=GO:0006468 |text = protein phosphorylation}} {{GNF_GO|id=GO:0006915 |text = apoptotic process}} {{GNF_GO|id=GO:0006917 |text = induction of apoptosis}} {{GNF_GO|id=GO:0006979 |text = response to oxidative stress}} {{GNF_GO|id=GO:0007059 |text = chromosome segregation}} {{GNF_GO|id=GO:0007568 |text = aging}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0009650 |text = UV protection}} {{GNF_GO|id=GO:0009791 |text = post-embryonic development}} {{GNF_GO|id=GO:0010467 |text = gene expression}} {{GNF_GO|id=GO:0016032 |text = viral reproduction}} {{GNF_GO|id=GO:0019048 |text = virus-host interaction}} {{GNF_GO|id=GO:0021510 |text = spinal cord development}} {{GNF_GO|id=GO:0022415 |text = viral reproductive process}} {{GNF_GO|id=GO:0030198 |text = extracellular matrix organization}} {{GNF_GO|id=GO:0030282 |text = bone mineralization}} {{GNF_GO|id=GO:0032289 |text = central nervous system myelin formation}} {{GNF_GO|id=GO:0033683 |text = nucleotide-excision repair, DNA incision}} {{GNF_GO|id=GO:0035264 |text = multicellular organism growth}} {{GNF_GO|id=GO:0035315 |text = hair cell differentiation}} {{GNF_GO|id=GO:0040016 |text = embryonic cleavage}} {{GNF_GO|id=GO:0043066 |text = negative regulation of apoptotic process}} {{GNF_GO|id=GO:0043249 |text = erythrocyte maturation}} {{GNF_GO|id=GO:0043388 |text = positive regulation of DNA binding}} {{GNF_GO|id=GO:0043588 |text = skin development}} {{GNF_GO|id=GO:0044281 |text = small molecule metabolic process}} {{GNF_GO|id=GO:0045893 |text = positive regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0045944 |text = positive regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0048820 |text = hair follicle maturation}} {{GNF_GO|id=GO:0050434 |text = positive regulation of viral transcription}} {{GNF_GO|id=GO:0060218 |text = hematopoietic stem cell differentiation}}
 | Hs_EntrezGene = 2068
 | Hs_Ensembl = ENSG00000104884
 | Hs_RefseqmRNA = NM_000400
 | Hs_RefseqProtein = NP_000391
 | Hs_GenLoc_db = hg19
 | Hs_GenLoc_chr = 19
 | Hs_GenLoc_start = 45853095
 | Hs_GenLoc_end = 45874176
 | Hs_Uniprot = P18074
 | Mm_EntrezGene = 13871
 | Mm_Ensembl = ENSMUSG00000030400
 | Mm_RefseqmRNA = NM_007949
 | Mm_RefseqProtein = NP_031975
 | Mm_GenLoc_db = mm9
 | Mm_GenLoc_chr = 7
 | Mm_GenLoc_start = 19382010
 | Mm_GenLoc_end = 19395694
 | Mm_Uniprot = O08811
 | path = PBB/2068
}}