编辑“︁SNAPC4”︁

{{Infobox_gene}}
'''snRNA激活蛋白复合体第四亚基'''（{{langx|en|'''snRNA-activating protein complex subunit 4'''}}）是一个由人类[[基因]] ''SNAPC4'' 编码的[[蛋白质]]<ref name="pmid9418884">{{cite journal | author = Wong MW, Henry RW, Ma B, Kobayashi R, Klages N, Matthias P, Strubin M, Hernandez N | title = The Large Subunit of Basal Transcription Factor SNAPc Is a Myb Domain Protein That Interacts with Oct-1 | url = https://archive.org/details/sim_molecular-and-cellular-biology_1998-01_18_1/page/368 | journal = Mol Cell Biol | volume = 18 | issue = 1 | pages = 368–77 | pmid = 9418884 | pmc = 121507 | doi =  |date=January 1998}}</ref><ref name="entrez">{{Cite web| title = Entrez Gene: SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6621| accessdate = }}</ref>。化学式为<ref>{{Cite web |title=Expasy - ProtParam |url=https://web.expasy.org/cgi-bin/protparam/protparam_bis.cgi?Q5SXM2@1-1469@ |website=web.expasy.org |access-date=2025-06-01}}</ref>：C<sub>6962</sub>H<sub>11203</sub>O<sub>2158</sub>N<sub>2075</sub>S<sub>29</sub><ref>{{Cite web |title=UniProt |url=https://www.uniprot.org/uniprotkb/Q5SXM2/entry |website=UniProt |language=en |access-date=2025-06-01}}</ref>

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==Model organisms==
{| class="wikitable sortable collapsible collapsed" border="1" cellpadding="2" style="float: right;" |
|+ ''Snapc4'' knockout mouse phenotype
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! Characteristic!! Phenotype

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| [[Homozygote]] viability || bgcolor="#C40000"|Abnormal
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| [[Recessive]] lethal study || bgcolor="#C40000"|Abnormal
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| Fertility || bgcolor="#488ED3"|Normal
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| Body weight || bgcolor="#488ED3"|Normal
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| [[Open Field (animal test)|Anxiety]] || bgcolor="#488ED3"|Normal
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| Neurological assessment || bgcolor="#488ED3"|Normal
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| Grip strength || bgcolor="#488ED3"|Normal
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| [[Hot plate test|Hot plate]] || bgcolor="#488ED3"|Normal
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| [[Dysmorphology]] || bgcolor="#488ED3"|Normal
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| [[Indirect calorimetry]] || bgcolor="#488ED3"|Normal
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| [[Glucose tolerance test]] || bgcolor="#488ED3"|Normal
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| [[Auditory brainstem response]] || bgcolor="#488ED3"|Normal
|-
| [[Dual-energy X-ray absorptiometry|DEXA]] || bgcolor="#488ED3"|Normal
|-
| [[Radiography]] || bgcolor="#488ED3"|Normal
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| Body temperature || bgcolor="#488ED3"|Normal
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| Eye morphology || bgcolor="#488ED3"|Normal
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| [[Clinical chemistry]] || bgcolor="#488ED3"|Normal
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| [[Blood plasma|Plasma]] [[immunoglobulin]]s || bgcolor="#488ED3"|Normal
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| [[Haematology]] || bgcolor="#488ED3"|Normal
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| [[Peripheral blood lymphocyte]]s || bgcolor="#488ED3"|Normal
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| [[Micronucleus test]] || bgcolor="#488ED3"|Normal
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| Heart weight || bgcolor="#488ED3"|Normal
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| Skin Histopathology || bgcolor="#488ED3"|Normal
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| Brain histopathology || bgcolor="#488ED3"|Normal
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| ''[[Salmonella]]'' infection || bgcolor="#488ED3"|Normal<ref name="''Salmonella'' infection">{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MBEZ/salmonella-challenge/ |title=''Salmonella'' infection data for Snapc4 |publisher=Wellcome Trust Sanger Institute}}</ref>
|-
| ''[[Citrobacter]]'' infection || bgcolor="#488ED3"|Normal<ref name="''Citrobacter'' infection">{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MBEZ/citrobacter-challenge/ |title=''Citrobacter'' infection data for Snapc4 |publisher=Wellcome Trust Sanger Institute}}</ref>
|-
| colspan=2; style="text-align: center;" | All tests and analysis from<ref name="mgp_reference">{{cite journal| doi = 10.1111/j.1755-3768.2010.4142.x| title = The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice| year = 2010| author = Gerdin AK| journal = Acta Ophthalmologica| volume = 88| issue = S248 }}</ref><ref>[http://www.sanger.ac.uk/mouseportal/ Mouse Resources Portal], Wellcome Trust Sanger Institute.</ref>
|}
[[Model organism]]s have been used in the study of SNAPC4 function. A conditional [[knockout mouse]] line, called ''Snapc4<sup>tm1a(KOMP)Wtsi</sup>''<ref name="allele_ref">{{cite web |url=http://www.knockoutmouse.org/martsearch/search?query=Snapc4 |title=International Knockout Mouse Consortium}}</ref><ref name="mgi_allele_ref">{{cite web |url=http://www.informatics.jax.org/searchtool/Search.do?query=MGI:4362491 |title=Mouse Genome Informatics}}</ref> was generated as part of the [[International Knockout Mouse Consortium]] program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the [[Wellcome Trust Sanger Institute]].<ref name="pmid21677750">{{Cite pmid|21677750}}</ref><ref name="mouse_library">{{cite journal |author=Dolgin E |title=Mouse library set to be knockout |url=https://archive.org/details/sim_nature-uk_2011-06-16_474_7351/page/262 |journal=Nature |volume=474 |issue=7351 |pages=262–3 |year=2011 |month=June |pmid=21677718 |doi=10.1038/474262a }}</ref><ref name="mouse_for_all_reasons">{{cite journal |author=Collins FS, Rossant J, Wurst W |title=A mouse for all reasons |journal=Cell |volume=128 |issue=1 |pages=9–13 |year=2007 |month=January |pmid=17218247 |doi=10.1016/j.cell.2006.12.018 }}</ref>

Male and female animals underwent a standardized [[phenotypic screen]] to determine the effects of deletion.<ref name="mgp_reference" /><ref name="pmid21722353">{{cite journal| author=van der Weyden L, White JK, Adams DJ, Logan DW| title=The mouse genetics toolkit: revealing function and mechanism. | journal=Genome Biol | year= 2011 | volume= 12 | issue= 6 | pages= 224 | pmid=21722353 | doi=10.1186/gb-2011-12-6-224  | pmc=3218837}}</ref> Twenty six tests were carried out on [[mutant]] mice and two significant abnormalities were observed. No [[homozygous]] mutant embryos were recorded during gestation and, in a separate study, no homozygous animals were observed at [[weaning]]. The remaining tests were carried out on adult [[heterozygous]] mutant animals and no further abnormalities were observed.<ref name="mgp_reference" />
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==相互作用==
SNAPC4能与[[SNAPC1]]<ref name=pmid11056176>{{cite journal |last=Ma |first=B |authorlink= |coauthors=Hernandez N |title=A map of protein-protein contacts within the small nuclear RNA-activating protein complex SNAPc |journal=J. Biol. Chem. |volume=276 |issue=7 |pages=5027–35 |publisher= |location = United States| issn = 0021-9258| pmid = 11056176 |doi = 10.1074/jbc.M009301200 | bibcode = | oclc =| id = | url =https://archive.org/details/sim_journal-of-biological-chemistry_2001-02-16_276_7/page/5026| language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |date=February 2001}}</ref>、[[POU2F1]]<ref name=pmid9418884>{{cite journal |last=Wong |first=M W |authorlink= |coauthors=Henry R W, Ma B, Kobayashi R, Klages N, Matthias P, Strubin M, Hernandez N |title=The Large Subunit of Basal Transcription Factor SNAPc Is a Myb Domain Protein That Interacts with Oct-1 |journal=Mol. Cell. Biol. |volume=18 |issue=1 |pages=368–77 |publisher= |location = UNITED STATES| issn = 0270-7306| pmid = 9418884 | bibcode = | oclc =| id = | url =https://archive.org/details/sim_molecular-and-cellular-biology_1998-01_18_1/page/368| language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=121507 |date=January 1998}}</ref><ref name=pmid11856838>{{cite journal |last=Hovde |first=Stacy |authorlink= |coauthors=Brooks Aimee, Strong Katie, Geiger James H |title=Crystallization of the Oct-1/SNAP190 peptide/DNA complex |journal=Acta Crystallogr. D Biol. Crystallogr. |volume=58 |issue=Pt 3 |pages=511–2 |publisher= |location = Denmark| issn = 0907-4449| pmid = 11856838 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1107/S0907444901021461 |date=March 2002}}</ref>和[[SNAPC2]]<ref name=pmid9418884/><ref name=pmid11056176/>[[蛋白質交互作用|相互作用]]。

==参考文献==
{{Reflist}}

==延伸阅读==
{{Refbegin| 2}}
{{PBB Further reading
| citations =
*{{Cite journal  | author=Henry RW, Sadowski CL, Kobayashi R, Hernandez N |title=A TBP-TAF complex required for transcription of human snRNA genes by RNA polymerase II and III | url=https://archive.org/details/sim_nature-uk_1995-04-13_374_6523/page/652 |journal=Nature |volume=374 |issue= 6523 |pages= 653–6 |year= 1995 |pmid= 7715707 |doi= 10.1038/374653a0 }}
*{{Cite journal  | author=Ma B, Hernandez N |title=A map of protein-protein contacts within the small nuclear RNA-activating protein complex SNAPc | url=https://archive.org/details/sim_journal-of-biological-chemistry_2001-02-16_276_7/page/5026 |journal=J. Biol. Chem. |volume=276 |issue= 7 |pages= 5027–35 |year= 2001 |pmid= 11056176 |doi= 10.1074/jbc.M009301200 }}
*{{Cite journal  | author=Hovde S, Brooks A, Strong K, Geiger JH |title=Crystallization of the Oct-1/SNAP190 peptide/DNA complex |journal=Acta Crystallogr. D Biol. Crystallogr. |volume=58 |issue= Pt 3 |pages= 511–2 |year= 2002 |pmid= 11856838 |doi=10.1107/S0907444901021461  }}
*{{Cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 | author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{Cite journal  | author=Hinkley CS |title=The small nuclear RNA-activating protein 190 Myb DNA binding domain stimulates TATA box-binding protein-TATA box recognition | url=https://archive.org/details/sim_journal-of-biological-chemistry_2003-05-16_278_20/page/18648 |journal=J. Biol. Chem. |volume=278 |issue= 20 |pages= 18649–57 |year= 2003 |pmid= 12621023 |doi= 10.1074/jbc.M204247200 | author2=Hirsch HA  | author3=Gu L  | display-authors=3  | last4=Lamere  | first4=B  | last5=Henry  | first5=RW }}
*{{Cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 | author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
*{{Cite journal  | author=Humphray SJ |title=DNA sequence and analysis of human chromosome 9 | url=https://archive.org/details/sim_nature-uk_2004-05-27_429_6990/page/368 |journal=Nature |volume=429 |issue= 6990 |pages= 369–74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465  | pmc=2734081 | author2=Oliver K  | author3=Hunt AR  | display-authors=3  | last4=Plumb  | first4=R. W.  | last5=Loveland  | first5=J. E.  | last6=Howe  | first6=K. L.  | last7=Andrews  | first7=T. D.  | last8=Searle  | first8=S.  | last9=Hunt  | first9=S. E. }}
*{{Cite journal  | author=Beausoleil SA |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101  | pmc=514446 | author2=Jedrychowski M  | author3=Schwartz D  | display-authors=3  | last4=Elias  | first4=JE  | last5=Villén  | first5=J  | last6=Li  | first6=J  | last7=Cohn  | first7=MA  | last8=Cantley  | first8=LC  | last9=Gygi  | first9=SP }}
*{{Cite journal  | author=Gu L, Esselman WJ, Henry RW |title=Cooperation between small nuclear RNA-activating protein complex (SNAPC) and TATA-box-binding protein antagonizes protein kinase CK2 inhibition of DNA binding by SNAPC | url=https://archive.org/details/sim_journal-of-biological-chemistry_2005-07-29_280_30/page/27696 |journal=J. Biol. Chem. |volume=280 |issue= 30 |pages= 27697–704 |year= 2005 |pmid= 15955816 |doi= 10.1074/jbc.M503206200 }}
*{{Cite journal  | author=Gu L, Husain-Ponnampalam R, Hoffmann-Benning S, Henry RW |title=The protein kinase CK2 phosphorylates SNAP190 to negatively regulate SNAPC DNA binding and human U6 transcription by RNA polymerase III | url=https://archive.org/details/sim_journal-of-biological-chemistry_2007-09-21_282_38/page/27886 |journal=J. Biol. Chem. |volume=282 |issue= 38 |pages= 27887–96 |year= 2007 |pmid= 17670747 |doi= 10.1074/jbc.M702269200 }}
}}
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