编辑“︁GRIA1”︁

{{Infobox gene}}
'''GRIA1'''({{langx|en|glutamate receptor, ionotropic, AMPA 1}})化学式为：C<sub>5005</sub>H<sub>7819</sub>O<sub>1704</sub>N<sub>1231</sub>S<sub>37</sub><ref>{{Cite web |title=Expasy - ProtParam |url=https://web.expasy.org/cgi-bin/protparam/protparam_bis.cgi?P42261@19-906@ |website=web.expasy.org｜基于一个通用的成熟双碱基复合型糖链模型（GlcNAc₄Man₃Gal₂Fuc₁Neu5Ac₂，单链净增长C₉₀H₁₄₆N₆O₆₅），在假设其 6个 N-糖基化位点均被完全修饰且形成 2个二硫键的理论模型下，该受体成熟形式的化学式为C₅₀₀₅H₇₈₁₉O₁₇₀₄N₁₂₃₁S₃₇ |access-date=2026-05-29}}</ref>，是由''GRIA1'' [[基因]]編碼的[[蛋白质]]。<ref name="pmid1652753">{{Cite journal |last=Puckett |first=C |last2=Gomez |first2=C M |last3=Korenberg |first3=J R |last4=Tung |first4=H |last5=Meier |first5=T J |last6=Chen |first6=X N |last7=Hood |first7=L |title=Molecular cloning and chromosomal localization of one of the human glutamate receptor genes. |url=https://pnas.org/doi/full/10.1073/pnas.88.17.7557 |journal=Proceedings of the National Academy of Sciences |language=en |date=1991-09 |volume=88 |issue=17 |page=7557-7561 |doi=10.1073/pnas.88.17.7557 |issn=0027-8424 |pmc=52340 |pmid=1652753}}</ref><ref name="pmid1319477">{{Cite journal |last=McNamara |first=Jo |last2=Eubanks |first2=Jh |last3=McPherson |first3=Jd |last4=Wasmuth |first4=Jj |last5=Evans |first5=Ga |last6=Heinemann |first6=Sf |title=Chromosomal localization of human glutamate receptor genes |url=https://www.jneurosci.org/lookup/doi/10.1523/JNEUROSCI.12-07-02555.1992 |journal=The Journal of Neuroscience |language=en |date=1992-07-01 |volume=12 |issue=7 |page=2555-2562 |doi=10.1523/JNEUROSCI.12-07-02555.1992 |issn=0270-6474 |pmc=6575855 |pmid=1319477}}</ref>

==交互作用==
GRIA1與以下蛋白質有[[蛋白質交互作用|交互作用]]:
* {{tsl|en|DLG1||DLG1}}<ref name="pmid12933808">{{Cite journal |last=Gardoni |first=Fabrizio |last2=Mauceri |first2=Daniela |last3=Fiorentini |first3=Chiara |last4=Bellone |first4=Camilla |last5=Missale |first5=Cristina |last6=Cattabeni |first6=Flaminio |last7=Luca |first7=Monica Di |title=CaMKII-dependent Phosphorylation Regulates SAP97/NR2A Interaction * |url=https://linkinghub.elsevier.com/retrieve/pii/S0021925820824995 |journal=Journal of Biological Chemistry |language=En |date=2003-11-07 |volume=278 |issue=45 |page=44745–44752 |doi=10.1074/jbc.M303576200 |issn=0021-9258 |pmid=12933808 |access-date=2025-01-30 |archive-date=2024-12-21 |archive-url=https://web.archive.org/web/20241221074554/https://linkinghub.elsevier.com/retrieve/pii/S0021925820824995 |dead-url=no }}</ref><ref name="pmid9677374">{{Cite journal |last=Leonard |first=A. Soren |last2=Davare |first2=Monika A. |last3=Horne |first3=M. C. |last4=Garner |first4=Craig C. |last5=Hell |first5=Johannes W. |title=SAP97 Is Associated with the α-Amino-3-hydroxy-5-methylisoxazole-4-propionic Acid Receptor GluR1 Subunit * |url=https://linkinghub.elsevier.com/retrieve/pii/S0021925818491351 |journal=Journal of Biological Chemistry |language=En |date=1998-07-31 |volume=273 |issue=31 |page=19518–19524 |doi=10.1074/jbc.273.31.19518 |issn=0021-9258 |pmid=9677374}}</ref><ref name="pmid11567040">{{Cite journal |last=Sans |first=Nathalie |last2=Racca |first2=Claudia |last3=Petralia |first3=Ronald S. |last4=Wang |first4=Ya-Xian |last5=McCallum |first5=Jennifer |last6=Wenthold |first6=Robert J. |title=Synapse-Associated Protein 97 Selectively Associates with a Subset of AMPA Receptors Early in their Biosynthetic Pathway |url=https://www.jneurosci.org/lookup/doi/10.1523/JNEUROSCI.21-19-07506.2001 |journal=The Journal of Neuroscience |language=en |date=2001-10-01 |volume=21 |issue=19 |page=7506-7516 |doi=10.1523/JNEUROSCI.21-19-07506.2001 |issn=0270-6474 |pmc=6762903 |pmid=11567040}}</ref>
* {{tsl|en|EPB41L2||EPB41L2}}<ref name="pmid11050113">{{Cite journal |last=Shen |first=Lei |last2=Liang |first2=Feng |last3=Walensky |first3=Loren D. |last4=Huganir |first4=Richard L. |title=Regulation of AMPA Receptor GluR1 Subunit Surface Expression by a 4.1N-Linked Actin Cytoskeletal Association |url=https://www.jneurosci.org/lookup/doi/10.1523/JNEUROSCI.20-21-07932.2000 |journal=The Journal of Neuroscience |language=en |date=2000-11-01 |volume=20 |issue=21 |page=7932-7940 |doi=10.1523/JNEUROSCI.20-21-07932.2000 |issn=0270-6474 |pmc=6772741 |pmid=11050113}}</ref>
* {{tsl|en|GRID2||GRID2}}<ref name="pmid12573530">{{Cite journal |last=Kohda |first=Kazuhisa |last2=Kamiya |first2=Yoshinori |last3=Matsuda |first3=Shinji |last4=Kato |first4=Kunio |last5=Umemori |first5=Hisashi |last6=Yuzaki |first6=Michisuke |title=Heteromer formation of δ2 glutamate receptors with AMPA or kainate receptors |url=https://linkinghub.elsevier.com/retrieve/pii/S0169328X02005612 |journal=Molecular Brain Research |date=2003-01-31 |volume=110 |issue=1 |page=27–37 |doi=10.1016/S0169-328X(02)00561-2 |issn=0169-328X |pmid=12573530 |access-date=2025-01-30 |archive-date=2025-01-04 |archive-url=https://web.archive.org/web/20250104030900/https://linkinghub.elsevier.com/retrieve/pii/S0169328X02005612 |dead-url=no }}</ref>

==參見==
* {{tsl|en|AMPA receptor||AMPA受體}}

==參考==
{{reflist|35em}}

==深入閱讀==
{{refbegin|35em}}
*{{cite journal |author=Sun W, Ferrer-Montiel AV, Schinder AF, McPherson JP, Evans GA, Montal M |title=Molecular cloning, chromosomal mapping, and functional expression of human brain glutamate receptors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue=4 |pages=1443–7 |year=1992 |pmid=1311100 |pmc=48467 |doi=10.1073/pnas.89.4.1443}}
*{{cite journal |author=Potier MC, Spillantini MG, Carter NP |title=The human glutamate receptor cDNA GluR1: cloning, sequencing, expression and localization to chromosome 5. |journal=DNA Seq. |volume=2 |issue=4 |pages=211–8 |year=1992 |pmid=1320959 |doi=10.3109/10425179209020805}}
*{{cite journal |author=Yakel JL, Vissavajjhala P, Derkach VA, Brickey DA, Soderling TR |title=Identification of a Ca2+/calmodulin-dependent protein kinase II regulatory phosphorylation site in non-N-methyl-D-aspartate glutamate receptors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue=5 |pages=1376–80 |year=1995 |pmid=7877986 |pmc=42522 |doi=10.1073/pnas.92.5.1376}}
*{{cite journal |author=Eastwood SL, Burnet PW, Beckwith J, Kerwin RW, Harrison PJ |title=AMPA glutamate receptors and their flip and flop mRNAs in human hippocampus. |journal=NeuroReport |volume=5 |issue=11 |pages=1325–8 |year=1994 |pmid=7919190 |doi=10.1097/00001756-199406270-00007}}
*{{cite journal |author=Roche KW, Raymond LA, Blackstone C, Huganir RL |title=Transmembrane topology of the glutamate receptor subunit GluR6. |url=https://archive.org/details/sim_journal-of-biological-chemistry_1994-04-22_269_16/page/11678 |journal=J. Biol. Chem. |volume=269 |issue=16 |pages=11679–82 |year=1994 |pmid=8163463 |doi=}}
*{{cite journal |author=McLaughlin DP, Cheetham ME, Kerwin RW |title=Expression of alternatively-spliced glutamate receptors in human hippocampus. |journal=Eur. J. Pharmacol. |volume=244 |issue=1 |pages=89–92 |year=1993 |pmid=8420792 |doi=10.1016/0922-4106(93)90062-E}}
*{{cite journal |author=Roche KW, O'Brien RJ, Mammen AL, Bernhardt J, Huganir RL |title=Characterization of multiple phosphorylation sites on the AMPA receptor GluR1 subunit. |journal=Neuron |volume=16 |issue=6 |pages=1179–88 |year=1996 |pmid=8663994 |doi=10.1016/S0896-6273(00)80144-0}}
*{{cite journal |author=Brakeman PR, Lanahan AA, O'Brien R, Roche K, Barnes CA, Huganir RL, Worley PF |title=Homer: a protein that selectively binds metabotropic glutamate receptors. |url=https://archive.org/details/sim_nature-uk_1997-03-20_386_6622/page/284 |journal=Nature |volume=386 |issue=6622 |pages=284–8 |year=1997 |pmid=9069287 |doi=10.1038/386284a0}}
*{{cite journal |author=Barria A, Derkach V, Soderling T |title=Identification of the Ca2+/calmodulin-dependent protein kinase II regulatory phosphorylation site in the alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate-type glutamate receptor. |journal=J. Biol. Chem. |volume=272 |issue=52 |pages=32727–30 |year=1998 |pmid=9407043 |doi=10.1074/jbc.272.52.32727}}
*{{cite journal |author=Ripellino JA, Neve RL, Howe JR |title=Expression and heteromeric interactions of non-N-methyl-D-aspartate glutamate receptor subunits in the developing and adult cerebellum. |journal=Neuroscience |volume=82 |issue=2 |pages=485–97 |year=1998 |pmid=9466455 |doi=10.1016/S0306-4522(97)00296-0}}
*{{cite journal |author=Leonard AS, Davare MA, Horne MC, Garner CC, Hell JW |title=SAP97 is associated with the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor GluR1 subunit. |url=https://archive.org/details/sim_journal-of-biological-chemistry_1998-07-31_273_31/page/19518 |journal=J. Biol. Chem. |volume=273 |issue=31 |pages=19518–24 |year=1998 |pmid=9677374 |doi=10.1074/jbc.273.31.19518}}
*{{cite journal |author=Xiao B, Tu JC, Petralia RS, Yuan JP, Doan A, Breder CD, Ruggiero A, Lanahan AA, Wenthold RJ, Worley PF |title=Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins. |journal=Neuron |volume=21 |issue=4 |pages=707–16 |year=1998 |pmid=9808458 |doi=10.1016/S0896-6273(00)80588-7}}
*{{cite journal |author=Montague AA, Greer CA |title=Differential distribution of ionotropic glutamate receptor subunits in the rat olfactory bulb. |journal=J. Comp. Neurol. |volume=405 |issue=2 |pages=233–46 |year=1999 |pmid=10023812 |doi=10.1002/(SICI)1096-9861(19990308)405:2<233::AID-CNE7>3.0.CO;2-A}}
*{{cite journal |author=Leuschner WD, Hoch W |title=Subtype-specific assembly of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor subunits is mediated by their n-terminal domains. |url=https://archive.org/details/sim_journal-of-biological-chemistry_1999-06-11_274_24/page/16906 |journal=J. Biol. Chem. |volume=274 |issue=24 |pages=16907–16 |year=1999 |pmid=10358037 |doi=10.1074/jbc.274.24.16907}}
*{{cite journal |author=Shi SH, Hayashi Y, Petralia RS, Zaman SH, Wenthold RJ, Svoboda K, Malinow R |title=Rapid spine delivery and redistribution of AMPA receptors after synaptic NMDA receptor activation. |url=https://archive.org/details/sim_science_1999-06-11_284_5421/page/1810 |journal=Science |volume=284 |issue=5421 |pages=1811–6 |year=1999 |pmid=10364548 |doi=10.1126/science.284.5421.1811}}
*{{cite journal |author=Rubio ME, Wenthold RJ |title=Calnexin and the immunoglobulin binding protein (BiP) coimmunoprecipitate with AMPA receptors. |journal=J. Neurochem. |volume=73 |issue=3 |pages=942–8 |year=1999 |pmid=10461883 |doi=10.1046/j.1471-4159.1999.0730942.x}}
*{{cite journal |author=Stinehelfer S, Vruwink M, Burette A |title=Immunolocalization of mGluR1alpha in specific populations of local circuit neurons in the cerebral cortex. |url=https://archive.org/details/sim_brain-research_2000-04-07_861_1/page/n44 |journal=Brain Res. |volume=861 |issue=1 |pages=37–44 |year=2000 |pmid=10751563 |doi=10.1016/S0006-8993(00)01952-1}}
{{refend}}

==外部連結==
* {{MeshName|GRIA1+protein,+human}}

{{NLM content}}
{{Ligand-gated ion channels}}

[[Category:离子通道]]