编辑“︁DEAD box”︁（章节）

==結構==
1980年代晚期有學者發現許多蛋白的{{le|NTP結合位點|NTP binding site}}序列和[[eIF4A]]RNA解旋酶的相似<ref name="pmid2546125">{{cite journal |vauthors=Gorbalenya AE, Koonin EV, Donchenko AP, Blinov VM | title = Two related superfamilies of putative helicases involved in replication, recombination, repair and expression of DNA and RNA genomes |url=https://archive.org/details/sim_nucleic-acids-research_1989-06-26_17_12/page/4712 | journal = Nucleic Acids Res. | volume = 17 | issue = 12 | pages = 4713–30 |date=June 1989 | pmid = 2546125 | pmc = 318027 | doi = 10.1093/nar/17.12.4713}}</ref>，後續研究發現這些蛋白均有9個[[保守序列|保守]]的結構域，由[[N端]]至[[C端]]分別為Q結構域、結構域I、結構域Ia、結構域Ib、結構域II、結構域III、結構域IV、結構域V與結構域VI，其中結構域II又名{{le|沃克結構域|Walker motifs|沃克結構域-B}}，包含天門冬胺酸-麩胺酸-丙胺酸-天門冬胺酸（DEAD）的氨基酸序列<ref name="pmid2563148"/>。Q結構域、結構域I、結構域II與結構域VI為結合與水解[[三磷酸腺苷|ATP]]所需，結構域Ia、結構域Ib、結構域III、結構域IV與結構域V則為結合RNA所需<ref name="pmid12535527">{{cite journal |vauthors=Tanner NK, Cordin O, Banroques J, Doère M, Linder P | title = The Q motif: a newly identified motif in DEAD box helicases may regulate ATP binding and hydrolysis | journal = Mol. Cell | volume = 11 | issue = 1 | pages = 127–38 |date=January 2003 | pmid = 12535527 | doi = 10.1016/S1097-2765(03)00006-6| doi-access = free }}</ref>。