编辑“︁5-HT4受體”︁（章节）

==配體==
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Several drugs that act as 5-HT<sub>4</sub> selective agonists have recently been introduced into use in both scientific research and clinical medicine. Some drugs that act as 5-HT<sub>4</sub> agonists are also active as 5-HT<sub>3</sub> antagonists, such as mosapride, metoclopramide, renzapride, and zacopride, and so these compounds cannot be considered highly selective. Research in this area is ongoing.<ref name="pmid19168624">{{cite journal | vauthors = Pellissier LP, Sallander J, Campillo M, Gaven F, Queffeulou E, Pillot M, Dumuis A, Claeysen S, Bockaert J, Pardo L | title = Conformational toggle switches implicated in basal constitutive and agonist-induced activated states of 5-hydroxytryptamine-4 receptors | journal = Molecular Pharmacology | volume = 75 | issue = 4 | pages = 982–90 | date = April 2009 | pmid = 19168624 | doi = 10.1124/mol.108.053686 }}</ref>

[[SB-207,145]] radiolabeled with [[碳的同位素|carbon-11]] is used as a {{tsl|en|radioligand||radioligand}} for 5-HT<sub>4</sub> in [[正电子发射计算机断层扫描|positron emission tomography]] pig<ref>{{cite journal | vauthors = Kornum BR, Lind NM, Gillings N, Marner L, Andersen F, Knudsen GM | title = Evaluation of the novel 5-HT4 receptor PET ligand [11C]SB207145 in the Göttingen minipig | journal = Journal of Cerebral Blood Flow and Metabolism | volume = 29 | issue = 1 | pages = 186–96 | date = January 2009 | pmid = 18797470 | doi = 10.1038/jcbfm.2008.110 }}</ref>
and human<ref name="pmid19470850">{{cite journal | vauthors = Marner L, Gillings N, Comley RA, Baaré WF, Rabiner EA, Wilson AA, Houle S, Hasselbalch SG, Svarer C, Gunn RN, Laruelle M, Knudsen GM | title = Kinetic modeling of 11C-SB207145 binding to 5-HT4 receptors in the human brain in vivo | url = https://archive.org/details/sim_journal-of-nuclear-medicine_2009-06_50_6/page/900 | journal = Journal of Nuclear Medicine | volume = 50 | issue = 6 | pages = 900–8 | date = June 2009 | pmid = 19470850 | doi = 10.2967/jnumed.108.058552 }}</ref>
studies.
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=== 激動劑 ===
* {{tsl|en|BIMU-8||BIMU-8}}
* {{tsl|en|Cisapride||Cisapride}}
* [[ML-10302]]<ref name="pmid21239110">{{cite journal | vauthors = Godínez-Chaparro B, Barragán-Iglesias P, Castañeda-Corral G, Rocha-González HI, Granados-Soto V | title = Role of peripheral 5-HT(4), 5-HT(6), and 5-HT(7) receptors in development and maintenance of secondary mechanical allodynia and hyperalgesia | journal = Pain | volume = 152 | issue = 3 | pages = 687–97 | date = March 2011 | pmid = 21239110 | doi = 10.1016/j.pain.2010.12.020 }}</ref>
* [[莫沙必利]]
* {{tsl|en|Prucalopride||Prucalopride}}
* {{tsl|en|Renzapride||Renzapride}}
* RS-67506
* {{tsl|en|Tegaserod||Tegaserod}}
* [[扎考必利|Zacopride]]
* [[Metoclopramide]]
* [[舒必利]]
* {{tsl|en|RS-67333||RS-67333}} - partial agonist
* {{tsl|en|SL65.0155||SL65.0155}} - partial agonist
* {{tsl|en|CJ-033,466||CJ-033,466}} - partial agonist

=== 拮抗劑 ===
* {{tsl|en|Piboserod||Piboserod}}
* {{tsl|en|GR-113,808||GR-113,808}} (1-methyl-1H-indole-3-carboxylic acid, [1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl]methyl ester)<ref>{{cite journal | vauthors = Gale JD, Grossman CJ, Whitehead JW, Oxford AW, Bunce KT, Humphrey PP | title = GR113808: a novel, selective antagonist with high affinity at the 5-HT4 receptor | url = https://archive.org/details/sim_british-journal-of-pharmacology_1994-01_111_1/page/332 | journal = British Journal of Pharmacology | volume = 111 | issue = 1 | pages = 332–8 | date = January 1994 | pmid = 8012715 | pmc = 1910004 | doi = 10.1111/j.1476-5381.1994.tb14064.x }}</ref>
* GR-125,487
* RS-39604 (1-[4-Amino-5-chloro-2-(3,5-dimethoxyphenyl)methyloxy]-3-[1-[2-methylsulphonylamino]piperidin-4-yl]propan-1-one)
* SB-203,186
* {{tsl|en|SB-204,070||SB-204,070}}
*([Methoxy-<sup>11</sup>C]1-butylpiperidin-4-yl)methyl 4-amino-3-methoxybenzoate<ref>{{cite journal | vauthors = Xu R, Hong J, Morse CL, Pike VW | title = Synthesis, structure-affinity relationships, and radiolabeling of selective high-affinity 5-HT4 receptor ligands as prospective imaging probes for positron emission tomography | journal = Journal of Medicinal Chemistry | volume = 53 | issue = 19 | pages = 7035–47 | date = October 2010 | pmid = 20812727 | pmc = 2951497 | doi = 10.1021/jm100668r }}</ref>
* 洋甘菊(酒精萃取)<ref>{{cite journal | vauthors = Simmen U, Kelber O, Okpanyi SN, Jaeggi R, Bueter B, Weiser D | year = | title = Binding of STW 5 (Iberogast) and its components to intestinal 5-HT, muscarinic M3, and opioid receptors | url = | journal = Phytomedicine| volume =  13 Suppl 5| issue = | pages =  51-5| pmid = 16973340 | doi=10.1016/j.phymed.2006.03.012}}</ref>